Publikationen

2017

Lühder F & Reichardt HM.
Novel drug delivery systems tailored for improved administration of glucocorticoids.
Int J Mol Sci, 18 (2017): pii E1836. doi: 10.3390/ijms18091836. [Pubmed]

Uri A, Werner S, Lühder F, Hünig T, Kerkau T, Beyersorf N.
Protection of mice from acute graft-versus-host disease requires CD28 co-stimulation on donor CD4+ Foxp3+ regulatory T cells.
Front Immunol, 8 (2017). doi: 10.3389/fimmu.2017.00721 [Epub ahead of print] [Pubmed]

Lagumersindez-Denis N, Wrzos C, Mack M, Winkler A, van der Meer F, Reinert MC, Hollasch H, Flach A, Brühl H, Cullen E, Schlumbohm C, Fuchs E, Linington C, Barrantes-Freer A, Metz I, Wegner C, Liebetanz D, Prinz M, Brück W, Stadelmann C, Nessler S.
Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis.
Acta Neuropathol, 134 (2017): 15-34. [Pubmed]

Klaßen C, Karabinskaya A, Dejager L, Vettorazzi S, Van Moorleghem J, Lühder F, Meijsing SH, Tuckermann JP, Bohnenberger H, Libert C, Reichardt HM.
Airway epithelial cells are crucial targets of glucocorticoids in a mouse model of allergic asthma.
J Immunol, 199 (2017): 48-61. [Pubmed]

Lodygin D, Flügel A.
Intravital real-time analysis of T-cell activation in health and disease.
Cell Calcium, 64 (2017): 118-129. [Pubmed]

Berghoff SA, Gerndt N, Winchenbach J, Stumpf SK, Hosang L, Odoardi F, Ruhwedel T, Böhler C, Barrette B, Stassart R, Liebetanz D, Dibaj P, Möbius W, Edgar JM, Saher G
Dietary cholesterol promotes repair of demyelinated lesions in the adult brain.
Nat Commun, 8 (2017): 14241. [Pubmed]

Engler JB, Kursawe N, Solano ME, Patas K, Wehrmann S, Heckmann N, Lühder F, Reichardt HM, Arck PC, Gold SM, Friese MA
Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.
Proc Natl Acad Sci USA, 114 (2017): E181-E190. [Pubmed]

Lühder F, Kebir H, Odoardi F, Litke T, Sonneck M, Alvarez JI, Winchenbach J, Eckert N, Hayardeny L, Sorani E, Lodygin D, Flügel A, Prat A.
Laquinimod enhances central nervous system barrier functions.
Neurobiol Dis, 102 (2017): 60-69. [Pubmed]

Montes-Cobos E, Ring S, Fischer HJ, Heck J, Strauß J, Schwaninger M, Reichardt SD, Feldmann C, Lühder F, Reichardt HM.
Targeted delivery of glucocorticoids to macrophages in a mouse model of multiple sclerosis using inorganic-organic hybrid nanoparticles.
J Control Release, 245 (2017): 157-169. [Pubmed]

2016

Winter M, Lodygin D, Verdoodt B, Hermeking H.
Deletion of 14-3-3σ sensitizes mice to DMBA/TPA-induced papillomatosis.
Oncotarget 7 (2016): 46862-46870. [Pubmed]

Flach A, Litke T, Strauss J, Haberl M, Cordero Gómez C, Reindl M, Saiz A, Fehling HJ, Wienands J, Odoardi F, Lühder F, Flügel A.
Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease.
Proc Natl Acad Sci USA, 113: 3323-3328. [Pubmed]

Schläger C, Körner H, Krueger M, Vidoli S, Haberl M, Mielke D, Brylla E, Issekutz T, Cabañas C, Nelson PJ, Ziemssen T, Rohde V, Bechmann I, Lodygin D, Odoardi F, Flügel A.
Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid.
Nature 530 (2016): 349-353. [Pubmed]

Engelhardt B, Carare RO, Bechmann I, Flügel A, Laman JD, Weller RO.
Vascular, glial, and lymphatic immune gateways of the central nervous system.
Acta Neuropathol 132 (2016): 317-338. [Pubmed]

Fröhlich M, Gogishvili T, Langenhorst D, Lühder F, Hünig T.
Interrupting CD28 costimulation before antigen rechallenge affects CD8(+) T-cell expansion and effector functions during secondary response in mice.
Eur J Immunol (2016): 1644-1655. [Pubmed]

Andresen L, Theodorou K, Grünewald S, Czech-Zechmeister B, Könnecke B, Lühder F, Trendelenburg G.
Evaluation of the therapeutic potential of anti-TLR4-antibody MTS510 in experimental stroke and significance of different routes of application.
PLOS One 11 (2016): doi: 10.1371/journal.pone.0148428. [Pubmed]

Fischer HJ, van den Brandt J, Lingner T, Odoardi F, Flügel A, Weishaupt A, Reichardt HM.
Modulation of CNS autoimmune responses by CD8(+) T cells coincides with their oligoclonal expansion.
J Neuroimmunol 290 (2016): 26-32. [Pubmed]

Schläger C, Litke T, Flügel A, Odoardi F.
In vivo visualization of (auto)immune processes in the central nervous system of rodents.
Methods Mol Biol 1304 (2016): 117-129. [Pubmed]

 

2015

Heuer L, Beyerbach M, Lühder F, Beineke A, Strube C.
Neurotoxocarosis alters myelin protein gene transcription and expression.
Parasitol Res 114 (2015): 2175-2186. [Pubmed]

Krey L, Lühder F, Kusch K, Czech-Zechmeister B, Könnecke B, Outeiro TF, Trendelenburg G.
Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice.
J Cereb Blood Flow Metab 35 (2015): 2080-2088. [Pubmed]

Linker RA, Lee H, Flach A, Litke T, van den Brandt J, Reichardt HM, Lingner T, Bommhardt U, Sendtner M, Gold R, Flügel A, Lühder F.
Thymocyte-derived BDNF influences T cell maturation at the DN3/DN4 transition stage.
Eur J Immunol 45 (2015): 1326-1338. [Pubmed]

Chan A & Lühder F.
Experimentelle Grundlagen neuroimmunologischer Erkrankungen.
In Fragen und Antworten zur Neuroimmunologie (Wiendl, H., Kieseier, B. C., and Meuth, S. G., eds) (2015): 7-26, Hogrefe Verlag, Bern.

Muth IE, Zschüntzsch J, Kleinschnitz K, Wrede A, Gerhardt E, Balcarek P, Schreiber-Katz O, Zierz S, Dalakas MC, Voll RE, Schmidt J.
HMGB1 and RAGE in skeletal muscle inflammation: Implications for protein accumulation in inclusion body myositis.
Exp Neurol 271 (2015): 189-197. [Pubmed]

Menzfeld C, John M, van Rossum D, Regen T, Scheffel J, Janova H, Götz A, Ribes S, Nau R, Borisch A, Boutin P, Neumann K, Bremes V, Wienands J, Reichardt HM, Lühder F, Tischner D, Waetzig V, Herdegen T, Teismann P, Greig I, Müller M, Pukrop T, Mildner A, Kettenmann H, Brück W, Prinz M, Rotshenker S, Weber MS, Hanisch UK.
Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism.
Glia 63 (2015): 1083-1099. [Pubmed]

Nebel M, Zhang B, Odoardi F, Flügel A, Potter BVL, Guse AH.
Calcium signalling triggered by NAADP in T cells determines cell shape and motility during immune synapse formation.
Messenger 4 (2015): 104-111.

Theiss-Suennemann J, Jörß K, Messmann JJ, Reichardt SD, Montes-Cobos E, Lühder F, Tuckermann JP, AWolff H, Dressel R, Gröne HJ, Strauß G, Reichardt HM.
Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8+ T cells.
J Pathology 235 (2015): 646-655. [Pubmed]

Wolf IM, Diercks BP, Gattkowski E, Czarniak F, Kempski J, Werner R, Schetelig D, Mittrücker HW, Schumacher V, von Osten M, Lodygin D, Flügel A, Fliegert R, Guse AH.
Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor.
Sci Signal 8 (2015): ra102. doi: 10.1126/scisignal.aab0863 [Pubmed]

 

2014

Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Ostmeier K, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, Nave KA, Ehrenreich H.
Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity.
Mol Psychiatry 19 (2014): 1143-1149. [Pubmed]

Reichardt SD, Weinhage T, Rotte A, Föller M, Oppermann M, Lühder F, Tuckermann JP, Lang F, van den Brandt J, Reichardt HM.
Glucocorticoids Induce Gastroparesis in Mice Through Depletion of l-Arginine.
Endocrinology 155 (2014): 3899-3908. [Pubmed]

Odoardi F, Neuhuber W, Flügel A.
Pain-induced skin autoimmunity.
Research Highlight in Cell Research 24 (2014): 1021-1022.[Pubmed]

Rokavec M, Oner MG, Li H, Jackstadt R, Jiang L, Lodygin D, Kaller M, Horst D, Ziegler PK, Schwitalla S, Slotta-Huspenina J, Bader FG, Greten FR, Hermeking H.
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.
J Clin Invest 124 (2014): 1853-1867. [Pubmed]

Uhmann A, Heß I, Frommhold A, König S, Zabel S, Nitzki F, Dittmann K, Lühder F, Christiansen H, Reifenberger J, Schulz-Schaeffer W, Hahn H.
DMBA/TPA Treatment Is Necessary for BCC Formation from Patched Deficient Epidermal Cells in Ptchflox/floxCD4Cre+/- Mice.
J Invest Dermatol. (2014); 134(10):2620-9. [Pubmed]

Lühder F & Gold R.
Trial and error in clinical studies: lesson from ATAMS.
Comment in Lancet Neurol 13 (2014): 340-341. [Pubmed]

Schweingruber N+, Fischer HJ+, Fischer L, van den Brandt J, Karabinskaya A, Labi V, Villunger A, Kretzschmar B, Huppke P, Simons M, Tickermann J, Flügel A, Lühder F*, Reichardt HM*.
Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses.
Acta Neuropathol 127 (2014): 713-729 +* equal contribution [Pubmed]

Carstens PO, Schmidt J.
Diagnosis, pathogenesis and treatment of myositis: recent advances.
Clin Exp Immunol 175 (2014): 349-358 [Pubmed]

Ndlovu H, Darby M, Froelich M, Horsnell W, Lühder F, Hünig T, Brombacher F.
Inducible deletion of CD28 prior to secondary Nippostrongylus brasiliensis invection impairs worm expulsion and recall of protective memory CD4+ T cell responses.
PLOS Pathogens 10 (2014): e1003906. [Pubmed]

Simma N, Bose T, Kahlfuß S, Mankiewicz J, Lowinus T, Lühder F, Schüler T, Schraven B, Heine M, Bommhardt U .
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
Cell Commun signal 12 (2014): 75. [Pubmed]

 

2013

Li W, Holsinger RM, Kruse CA, Flügel A, Graeber MB.
The potential for genetically altered microglia to influence glioma treatment.
CNS Neurol Disord Drug Targets 12 (2013): 750-762. [Pubmed]

Fischer HJ, Schweingruber N, Lühder F, Reichardt HM.
The potential role of T cell migration and chemotaxis as targets of glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis.
Mol Cell Endocrinol 380 (2013): 99-107. [Pubmed]

Lodygin D, Odoardi F, Schläger C, Körner H, Kitz A, Nosov M, van den Brandt J, Reichardt HM, Haberl M, Flügel A.
A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity.
Nat Med 19 (2013): 784-790. [Pubmed]

Fang H, Liu A, Sun J, Kitz A, Dirsch O, Dahmen U.
Granulocyte colony stimulating factor induces lipopolysaccharide (LPS) sensitization via upregulation of LPS binding protein in rat.
PLoS One 8 (2013): e56654. doi: 10.1371/journal.pone.0056654. Epub 2013 Feb 20. [Pubmed]

Gogishvili T, Lühder F, Goebbels S, Beer-Hammer S, Pfeffer K, Hünig T.
Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by induced CD28 deletion.
Eur J Immunol 43 (2013): 188-193. [Pubmed] David Sansom & Lucy Walker commentary [Pubmed commentary]

Lühder F, Gold R, Flügel A, Linker RA.
Brain-Derived Neurotrophic Factor in Neuroimmunology: Lessons Learned from Multiple Sclerosis Patients and Experimental Autoimmune Encephalomyelitis Models.
Arch Immunol Ther Exp (Warsz). 2013 Apr;61(2):95-105 [Pubmed]

 

2012

Graeber MB, Banati RB, Flügel A, Streit WJ, Tetzlaff W.
Courage, luck and patience: in celebration of the 80th birthday of Georg W. Kreutzberg.
Acta Neuropathol 124 (2012): 593-598. [Pubmed]

Gogishvili T, Lühder F, Kirstein F, Nieuwenhuizen NE, Goebbels S, Beer-Hammer S, Pfeffer K, Reuter S, Taube C, Brombacher F, Hünig T.
Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease.
J Allergy Clin Immunol 130 (2012): 1394-1403. [Pubmed]

Wüst S, van den Brandt J, Reichardt HM, Lühder F.
Preventive treatment with methylprednisolone paradoxically exacerbates experimental autoimmune encephalomyelitis.
J Endocrinol (2012): doi: 10.1155/2012/417017. [Pubmed]

Reichardt HM, Lühder F.
The ambivalent role of apoptosis in experimental autoimmune encephalomyelitis and multiple sclerosis.
Curr Pharm Des 18 (2012): 4453-4464. [Pubmed]

Odoardi F, Sie C, Streyl K, Ulaganathan VK, Schläger C, Lodygin D, Heckelsmiller K, Nietfeld W, Ellwart J, Klinkert WE, Lottaz C, Nosov M, Brinkmann V, Spang R, Lehrach H, Vingron M, Wekerle H, Flügel-Koch C, Flügel A.
T cells become licensed in the lung to enter the central nervous system.
Nature 488 (2012): 675-679. [Pubmed]. Richard M. Ransohoff commentary in Nature.

Treacy O, Ryan AE, Heinzl T, O’Flynn L, Cregg M, Wilk M, Odoardi F, Lohan P, O’Brien T, Nosov M, Ritter T.
Adenoviral transduction of mesenchymal stem cells: in vitro responses and in vivo immune responses after cell transplantation.
PLoS One. 2012;7(8):e42662. Epub 2012 Aug 6. [Pubmed]

Frank T, Klinker F, Falkenburger BH, Laage R, Lühder F, Göricke B, Schneider A, Neurath H, Desel H, Liebetanz D, Bähr M, Weishaupt JH.
Pegylated granulocyte colony-stimulating factor conveys long-term neuroprotection and improves functional outcome in a model of Parkinson’s disease.
Brain 135 (2012): 1914-1925. [Pubmed]

Schmidt J, Barthel K, Zschüntzsch J, Muth I, Swindle E, Hombach A, Sehmisch S, Wrede A, Lühder F, Gold R, Dalakas M.
Nitric oxide stress in sporadic inclusion body myositis muscle fibres: inhibition of inducible nitric oxide synthase prevents interleukin-1beta-induced accumulation of beta-amyloid and cell death.
Brain 135 (2012): 1102-1114. [Pubmed]

Wekerle H, Flügel A, Fugger L, Schett G, Serreze D.
Autoimmunity’s next top models.
Nature Medicine 18 (2012): 66-70. [Pubmed]

Lee DH, Geyer E, Flach AC, Jung K, Gold R, Flügel A, Linker RA, Lühder F.
Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination.
Acta Neuropathol 123 (2012) 247-258 [Pubmed]

Schweingruber N, Reichardt SD, Lühder F, Reichardt HM.
Mechanisms of glucocorticoids in the control of neuroinflammation.
J Neuroendocrinol. 24 (2012): 174-182. [Pubmed]

 

2011

Flügel A, Schläger C, Lühder F, Odoard Fi.
Autoimmune disease in the brain – how to spot the culprits and how to keep them in check.
Journal of Neurological Sciences 311 S1(2011): S3–S11.

Tischner D, Theiss J, Karabinskaya A, van den Brandt J, Reichardt SD, Karow U, Herold MJ, Lühder F, Utermöhlen O, Reichardt HM.
Acid sphingomyelinase is required for protection of effector memory T cells against glucocorticoid-induced cell death.
J Immunol (2011) doi: 10.4049/ J Immunol 187 (2011):4509-4516. [Pubmed]

Schweingruber N, Haine A, Tiede K, Karabinskaya A, van den Brandt J, Wüst S, Metselaar JM, Gold R, Tuckermann JP, Reichardt HM, Lühder F.
Liposomal Encapsulation of Glucocorticoids Alters Their Mode of Action in the Treatment of Experimental Autoimmune Encephalomyelitis.
J Immunol 187 (2011):4310-4318. [Pubmed]

Miljkovic D, Stanojevic Z, Momcilovic M, Odoardi F, Flügel A, Mostarica-Stojkovic M.
CXCL12 expression within the CNS contributes to the resistance against experimental autoimmune encephalomyelitis in Albino Oxford rats.
Immunobiology 216 (2011): 979-987. [Pubmed]

Keller CW, Fokken C, , Turville S, Lünemann A, Schmidt J, Münz C, Lünemann JD.
TNF-alpha induces macroautophagy and regulates MHC class II expression in human skeletal muscle cells.
J Biol Chem 286 (2011): 3970-3980. [Pubmed]

Uhmann A, van den Brandt J, Dittmann K, Hess I, Dressel R, Binder C, Lühder F, Christiansen H, Fassnacht M, Bhandoola A, Wienands J, Reichardt HM, Hahn H.
T cell development critically depends on prethymic stromal patched expression.
J Immunol 186 (2011) 3383-91. [Pubmed]

 

2010 – 2004

Für eine Gesamtpublikationsliste des Instituts in den Jahren 2004-2010 klicken Sie bitte hier